Key result
Assessment of endothelial dysfunction provides important insights into the pathogenesis of cardiovascular disorders, though specific clinical implications and limitations require careful consideration.
This review provides an overview of the methods, implications, and limitations of assessing endothelial dysfunction in cardiovascular disorders.
Endothelial dysfunction assessment merits cautious clinical interpretation; leaves open its role in routine risk stratification pending prospective validation.
The pathophysiology underlying the initiation and progression of cardiovascular disorders is highly complex and multifactorial. The endothelium also plays a crucial role in the pathogenesis of thrombogenesis and atherogenesis, and a continuum of endothelial activation, dysfunction or damage is evident in many cardiovascular disorders both at the macro and microscopic level(s). This review article aims to provide an overview of the assessment of endothelial (dys)function and discuss the implications and limitations of such assessments.
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Freestone et al. (2010) conducted a review in Cardiovascular disorders. Assessment of endothelial dysfunction was evaluated. Assessment of endothelial dysfunction provides important insights into the pathogenesis of cardiovascular disorders, though specific clinical implications and limitations require careful consideration.
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