Why the study?
Further studies are needed to comprehensively characterize the impact of CRT on left atrial phasic function and strain, as well as its relation to functional mitral regurgitation and LV diastolic dysfunction.
Does cardiac resynchronization therapy improve left atrial remodeling in patients with heart failure, systolic dysfunction, and prolonged QRS interval?
Does cardiac resynchronization therapy improve left atrial remodeling in patients with heart failure, systolic dysfunction, and prolonged QRS interval?
This review highlights that CRT improves left atrial function and strain, particularly in responders, and that LA volumes can predict CRT responsiveness.
Cardiac resynchronization therapy (CRT) restores ventricular dyssynchrony, improving left ventricle (LV) systolic function, symptoms, and outcome in patients with heart failure, systolic dysfunction, and prolonged QRS interval. The left atrium (LA) plays tremendous roles in maintaining cardiac function, being often inflicted in various cardiovascular diseases. LA remodeling implies structural-dilation, functional-altered phasic functions, and strain and electrical-atrial fibrillation remodeling. Until now, several important studies have approached the relationship between LA and CRT. LA volumes can predict responsiveness to CRT, being also associated with improved outcome in these patients. LA function and strain parameters have been shown to improve after CRT, especially in those who were positive responders to it. Further studies still need to be conducted to comprehensively characterize the impact of CRT on LA phasic function and strain, and, also, in conjunction with its impact on functional mitral regurgitation and LV diastolic dysfunction. The aim of this review was to provide an overview of current available data regarding the relation between CRT and LA remodeling.
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Radu et al. (2023) studied this question.
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