Key result
Circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improved freedom from recurrent atrial fibrillation or flutter at 1 year compared to control (74% vs 58%, P=0.05).
Why the study?
Does circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improve freedom from recurrent atrial fibrillation or flutter in patients with chronic atrial fibrillation?
RCT (n=146)
randomly assigned
Does circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improve freedom from recurrent atrial fibrillation or flutter in patients with chronic atrial fibrillation?
Absolute Event Rate: 74% vs 58%
p-value: p=0.05
Circumferential pulmonary-vein ablation improves the long-term maintenance of sinus rhythm in patients with chronic atrial fibrillation, leading to decreased symptom severity and left atrial diameter.
No takes yet. Share an insight, caveat, or question.
Supports adding ablation to amiodarone and cardioversion in chronic AF; extends randomized evidence for sinus-rhythm maintenance.
Oral et al. (2006) conducted an RCT in chronic atrial fibrillation (n=146). Circumferential pulmonary-vein ablation vs. Amiodarone and two cardioversions alone was evaluated on Freedom from recurrent atrial fibrillation or flutter without antiarrhythmic-drug therapy at one year (p=0.05). Circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improved freedom from recurrent atrial fibrillation or flutter at 1 year compared to control (74% vs 58%, P=0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: