Key result
Circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improved freedom from recurrent atrial fibrillation or flutter at 1 year compared to control (74% vs 58%, P=0.05).
Why the study?
Does circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improve freedom from recurrent atrial fibrillation or flutter in patients with chronic atrial fibrillation?
Population
n=146 patients with chronic atrial fibrillation, mean age 57+/-9 years
Comparison
Circumferential pulmonary-vein ablation in… vs Amiodarone and two cardioversions during the…
Design
RCT, randomly assigned
Follow-up
one year
Authors
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Supports adding ablation to amiodarone and cardioversion in chronic AF; extends randomized evidence for sinus-rhythm maintenance.
RCT (n=146)
randomly assigned
Does circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improve freedom from recurrent atrial fibrillation or flutter in patients with chronic atrial fibrillation?
Absolute Event Rate: 74% vs 58%
p-value: p=0.05
Circumferential pulmonary-vein ablation improves the long-term maintenance of sinus rhythm in patients with chronic atrial fibrillation, leading to decreased symptom severity and left atrial diameter.
Oral et al. (2006) conducted an RCT in chronic atrial fibrillation (n=146). Circumferential pulmonary-vein ablation vs. Amiodarone and two cardioversions alone was evaluated on Freedom from recurrent atrial fibrillation or flutter without antiarrhythmic-drug therapy at one year (p=0.05). Circumferential pulmonary-vein ablation combined with amiodarone and cardioversion improved freedom from recurrent atrial fibrillation or flutter at 1 year compared to control (74% vs 58%, P=0.05).
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