Key result
Pulmonary vein disconnection combined with a mitral isthmus line significantly improved the 1-year arrhythmia-free rate compared to PVD alone (71% vs 53%; P=0.01).
Why the study?
Does pulmonary vein disconnection combined with mitral isthmus line ablation improve arrhythmia-free survival in patients with paroxysmal or persistent atrial fibrillation?
Population
187 patients with paroxysmal or persistent atrial fibrillation, mean age 55 +/- 11 years, 37 females.
Comparison
Pulmonary vein disconnection combined with… vs Pulmonary vein disconnection alone using an…
Design
RCT, prospectively randomized into two groups
Follow-up
1 year
Authors
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Supports adding mitral isthmus line to PVD for higher arrhythmia-free survival in AF; extends RCT evidence for linear ablation beyond PVI.
RCT (n=187)
Does pulmonary vein disconnection combined with mitral isthmus line ablation improve arrhythmia-free survival in patients with paroxysmal or persistent atrial fibrillation?
Absolute Event Rate: 71% vs 53%
p-value: p=0.01
The addition of a mitral isthmus line to pulmonary vein disconnection significantly improves 1-year sinus rhythm maintenance in patients with atrial fibrillation, particularly those with persistent AF.
Fassini et al. (2005) conducted an RCT in Paroxysmal or persistent atrial fibrillation (n=187). Pulmonary vein disconnection combined with mitral isthmus line vs. Pulmonary vein disconnection alone was evaluated on Arrhythmia free at 1 year (p=0.01). Pulmonary vein disconnection combined with a mitral isthmus line significantly improved the 1-year arrhythmia-free rate compared to PVD alone (71% vs 53%; P=0.01).
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