What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary artery bypass grafting (n=2129). Intervention: Female sex vs. Male sex. Primary outcome: Mortality during the 30 days after coronary artery bypass grafting (p=< 0.05).

What question did this study set out to answer?

This study aims to analyze the relationship between gender and outcomes following coronary artery bypass grafting over a two-year period.

September 1, 1996European Heart JournalOpen Access

Female sex is associated with increased mortality and morbidity early, but not late, after coronary artery bypass grafting

Q: What are the key findings of this study?

Female sex was a significant independent predictor of 30-day mortality after coronary artery bypass grafting (P<0.05), but did not influence late mortality up to 2 years.

Q: What question did this study set out to answer?

This study aims to analyze the relationship between gender and outcomes following coronary artery bypass grafting over a two-year period.

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Key result

Female sex was a significant independent predictor of 30-day mortality after coronary artery bypass grafting (P<0.05), but did not influence late mortality up to 2 years.

Why the study?

Is female sex associated with increased mortality and morbidity in patients undergoing coronary artery bypass grafting compared to male sex?

Population

2,129 consecutive patients undergoing coronary artery bypass surgery without concomitant procedures in…

Comparison

Female sex (observational exposure) vs Male sex

Design

Cohort

Follow-up

2 years

Authors

GBGunnar Brandrup‐WognsenGeneral / Preventive / Lipids HBHåkan BerggrenDrottning Silvias barn- och ungdomssjukhus MHMarianne HartfordUniversity of Gothenburg

Discussion

Member takes

Implication

Female sex may warrant heightened early perioperative vigilance after CABG; leaves open whether sex-specific strategies alter long-term survival.

Key Points

This study aims to analyze the relationship between gender and outcomes following coronary artery bypass grafting over a two-year period.
Prospective follow-up study
Analyzed data from 2129 patients (81% men and 19% women) undergoing surgery
Multivariate analysis considering age and medical history conducted for complications assessment.
Females had a higher mortality risk within 30 days (P < 0.05) compared to males.
Postoperative complications were more frequent in females, including neurological deficits and myocardial damage.
Late mortality rates were similar between genders, indicating that long-term benefits are comparable.

Study Design

Type

Cohort (n=2,129)

Multicenter

Yes

Structured PICO

Is female sex associated with increased mortality and morbidity in patients undergoing coronary artery bypass grafting compared to male sex?

Population

2,129 consecutive patients (1,727 men [81%], 402 women [19%]) undergoing coronary artery bypass surgery without concomitant procedures in western Sweden between June 1988 and June 1991.

Intervention

Female sex (observational exposure)

Comparator

Male sex

Outcome

Mortality and morbidity during a period of 2 years after coronary artery bypass graftinghard clinical

Main Result

p-value: p=< 0.05

Female sex is an independent predictor of 30-day mortality and early postoperative complications after CABG, but does not negatively impact late mortality up to 2 years.

Cite This Study

Brandrup‐Wognsen et al. (1996) conducted a cohort in Coronary artery bypass grafting (n=2,129). Female sex vs. Male sex was evaluated on Mortality during the 30 days after coronary artery bypass grafting (p=< 0.05). Female sex was a significant independent predictor of 30-day mortality after coronary artery bypass grafting (P<0.05), but did not influence late mortality up to 2 years.

synapsesocial.com/papers/6a0eb72c7046b28dbef9a0bb https://doi.org/10.1093/oxfordjournals.eurheartj.a015078

Topics

Women and heart disease

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Implication

Female sex may warrant heightened early perioperative vigilance after CABG; leaves open whether sex-specific strategies alter long-term survival.

Female sex is associated with increased mortality and morbidity early, but not late, after coronary artery bypass grafting

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Female sex is associated with increased mortality and morbidity early, but not late, after coronary artery bypass grafting

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

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