Key result
Second-degree AVB is linked to a ~17-fold higher risk of AF.
Why the study?
The relationship between atrioventricular conduction block and AF remains controversial.
Is atrioventricular block associated with an increased risk of clinical atrial fibrillation?
Case-Control (n=1,243)
Is atrioventricular block associated with an increased risk of clinical atrial fibrillation?
Effect estimate: Risk 16.845 (95% CI 6.099-46.524)
p-value: p=<0.000
Atrioventricular block, particularly type II, is significantly associated with the occurrence of atrial fibrillation and may serve as a risk predictor.
AVB was associated with higher AF risk; hypothesis-generating for its role as predictor, needing prospective validation.
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with its incidence making up nearly one-third of all hospital admissions. Atrioventricular block (AVB) is a conduction abnormality along the atrioventricular node or the His-Purkinje system. The relationship between atrioventricular conduction block and AF is controversial. HYPOTHESIS: This study is designed to observe whether there is a correlation between AVB and AF, and which type of AVB has the most obvious correlation with AF. METHODS: This study retrospectively reviewed 1345 patients. We classified the AVB according to the AVB classification criteria. One hundred and two patients were excluded, and the final total sample size was 1243 patients, including 679 patients in the AF group (378, 55.7% males) and 564 patients in the non-AF group (287, 50.8% males). AF group and non-AF group were compared to observe the relationship between AVB and AF. RESULTS: The I AVB have a relative statistical risk of 1.927 (95% confidence interval [CI]: 1.160-3.203, P < 0.05) with the occurrence of AF. II AVB occupied the largest proportion, accounting for 67 cases (9.87%), and the statistical risk of II AVB in AF is 16.845 (95% CI: 6.099-46.524, P < 0.000). III AVB has a comparative statistical risk of 17.599 (95% CI: 4.212-73.541, P < 0.000). CONCLUSIONS: The three types of AVB in the AF group were significantly higher than that in the non-AF group. II AVB has the highest incidence rate compared with other types of AVB in the AF group. AVB can be used as a risk factor for AF occurrence.
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Zhao et al. (2019) conducted a case-control in Atrial fibrillation (n=1,243). Atrioventricular block (AVB) vs. Non-AF group was evaluated on Occurrence of atrial fibrillation (Risk 16.845, 95% CI 6.099-46.524, p=<0.000). Atrioventricular block was significantly associated with atrial fibrillation, with second-degree AVB showing a statistical risk of 16.845 (95% CI 6.099-46.524; P<0.000).
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