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October 21, 1982New England Journal of Medicine318 citations

Dilated Cardiomyopathies of the Adult

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RJRobert A. JohnsonIPIgor F. Palacios

Key Result

Dilated cardiomyopathy is defined as a disorder directly affecting the cardiac ventricles, producing heart failure from myocardial disease rather than extrinsic disorders.

Key Points

  • To define and classify adult cardiomyopathies, specifically distinguishing primary myocardial disorders affecting the cardiac ventricles from extrinsic causes of heart failure.
  • Clinical and linguistic review evaluating the diagnostic boundaries and conceptual framework of myocardial diseases.
  • Comparative analysis distinguishing primary intrinsic ventricular disease from secondary extrinsic causes such as hypertension, shunts, pericardial disorders, and valvular conditions.
  • Cardiomyopathy is defined as a disorder directly affecting one or both cardiac ventricles in a diffuse or multifocal pattern, leading to heart failure in a subset of patients.
  • The clinical utility of the term depends on specifying heart failure originating from intrinsic myocardial disease rather than extrinsic mechanical or circulatory factors.

Structured PICO

P
Population
Adults with dilated cardiomyopathy

Provides a definition and clinical context for dilated cardiomyopathies in adults.

Abstract

Cardiomyopathies are diseases of the myocardium. We use the term "cardiomyopathy" here to refer to a disorder that directly affects one or both cardiac ventricles in a diffuse or multifocal fashion, and that produces heart failure at least in some patients. This definition embraces both the linguistic roots of the word and the clinical context in which the concept of cardiomyopathy is most useful — namely, in specifying those instances in which heart failure results from a myocardial disease rather than from an extrinsic disorder, such as valvular disease, a circulatory shunt, pericardial disease, uncontrolled hypertension, . . .

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Cite This Study

Johnson et al. (1982) conducted a review in Dilated Cardiomyopathies. Dilated cardiomyopathy is defined as a disorder directly affecting the cardiac ventricles, producing heart failure from myocardial disease rather than extrinsic disorders.

synapsesocial.com/papers/6a0eb83a06ecbe833447bcb1https://doi.org/10.1056/nejm198210213071704
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Also Consider

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  1. 1Cardiac sarcoid: a clinicopathologic study of 84 unselected patients with systemic sarcoidosis.1978 · 989 citations
  2. 2Long-Term Digitalis Therapy Improves Left Ventricular Function in Heart Failure1980 · 299 citations
  3. 3Chagas' Disease1956 · 487 citations
  4. 4The cardiomyopathies.1972 · 243 citations
  5. 5Clinical profile of restrictive cardiomyopathy.1980 · 172 citations