Key result
This article reviews the development of cardiac cell models and software tools created to facilitate the cardiac Physiome Project, inspired by the Hodgkin-Huxley equations.
This review highlights the historical evolution of cardiac cell modeling from the Hodgkin-Huxley equations to the comprehensive Cardiac Physiome Project.
Informs cardiac modeling tools for researchers; leaves open clinical translation and validation in practice.
Early modelling of cardiac cells (1960-1980) was based on extensions of the Hodgkin-Huxley nerve axon equations with additional channels incorporated, but after 1980 it became clear that processes other than ion channel gating were also critical in generating electrical activity. This article reviews the development of models representing almost all cell types in the heart, many different species, and the software tools that have been created to facilitate the cardiac Physiome Project.
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Noble et al. (2012) conducted a review in Cardiac cell modelling. This article reviews the development of cardiac cell models and software tools created to facilitate the cardiac Physiome Project, inspired by the Hodgkin-Huxley equations.
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