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September 1, 1981IEEE Transactions on Biomedical Engineering

Alteration in Sodium Channel Gate Kinetics of the Hodgkin-Huxley Equations Applied to an Electric Field Model for Interaction Between Excitable Cells

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Population

Computational electric field model of adjacent myocardial cells (expanded to a chain of six cells)

Design

Preclinical

Authors

JMJames E. MannUniversity of Colorado Anschutz Medical CampusNSNick SperelakisUniversity of VirginiaJRJames A. RuffnerUnited States Department of the Army

Discussion

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Overview

Does not yet inform clinical arrhythmia models; leaves open validation of junctional membrane propagation in intact hearts.

Structured PICO

P
Population
Computational electric field model of adjacent myocardial cells (expanded to a chain of six cells)
I
Intervention
Modification of the dynamics of the fast sodium channel gates of the junctional membranes (controlled by the m and h parameters)
O
Outcome
Propagation of an electrical impulse and propagation velocity

An electric field model based on closely apposed and excitable junctional membranes can account for electrical propagation in cardiac muscle without requiring low-resistance connections.

Cite This Study

Mann et al. (1981) studied this question.

synapsesocial.com/papers/6a9449499fbe5f86ceb9694ehttps://doi.org/10.1109/tbme.1981.324756
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling2010 · 94 citations
  2. 2A model study of electric field interactions between cardiac myocytes1992 · 26 citations
  3. 3A Primitive Model for Predicting Membrane Currents in Excitable Cells Based Only on Ion Diffusion Coefficients2024
  4. 4Electric field interactions between closely abutting excitable cells2002 · 72 citations
  5. 5Characterizing parameters and incorporating action potentials via the Hodgkin-Huxley model in a novel electric model for living cells2024 · 4 citations