Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1992IEEE Transactions on Biomedical Engineering

A model study of electric field interactions between cardiac myocytes

View Full Paper
Ask AI
Bookmark
Share

Key result

A computational model of two abutted cardiac myocytes was developed to examine how the physical characteristics of the intercellular gap affect electric field coupling and excitation transmission.

Population

Computational model comprising two cardiac myocytes abutted end-to-end in an unbounded volume conductor…

Design

Preclinical

Authors

HHHervé HoguesUniversité du Québec à MontréalLLL.J. LeonGovernment of ExtremaduraFRF.A. RobergePolytechnique Montréal

Discussion

Loading...

Member takes

Implication

Does not inform clinical conduction management; leaves open gap geometry effects for future in vivo modeling.

Key Points

  • This study aims to investigate how physical characteristics of intercellular gaps affect electric field coupling between cardiac myocytes.
  • A model of two myocytes was created with no resistive coupling, using the Beeler-Reuter model for Na+ current dynamics.
  • Each myocyte was modeled as a small cylinder of membrane, with the intercellular junction featuring closely apposed membranes.
  • Various sizes of intercellular gaps and membrane folding were tested to observe their effects on excitation transmission.
  • Increased size of the intercellular gap diminished the field coupling effect, impacting subsequent excitation in the post-junctional cell.
  • Changes in membrane folding were also associated with variations in excitation development.
  • The computational model provided insights into the dynamics of ionic currents during electric field interactions.

Structured PICO

P
Population
Computational model comprising two cardiac myocytes abutted end-to-end in an unbounded volume conductor, using a modified Beeler-Reuter model for membrane ionic current.
E
Exposure
Variation of the physical characteristics of the intercellular gap (size and extent of membrane folding).
O
Outcome
Effect on field coupling and possible development of excitation in the post-junctional cell.

This computational study aims to model how the physical characteristics of the intercellular gap affect electric field coupling and excitation transmission between cardiac myocytes.

Cite This Study

Hogues et al. (1992) studied Cardiac electrophysiology. Physical characteristics of the intercellular gap was evaluated on Effect of field coupling and excitation development in the post-junctional cell. A computational model of two abutted cardiac myocytes was developed to examine how the physical characteristics of the intercellular gap affect electric field coupling and excitation transmission.

synapsesocial.com/papers/6a22a092a1bd7ea8dd119f80https://doi.org/10.1109/10.184699
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reconstruction of the action potential of ventricular myocardial fibres1977 · 1,436 citations
  2. 2Contractile properties of single isolated feline ventriculocytes1988 · 19 citations
  3. 3A model study of extracellular stimulation of cardiac cells1993 · 41 citations
  4. 4Action potential transfer in cell pairs isolated from adult rat and guinea pig ventricles.1988 · 94 citations
  5. 5Measurement of Single Channel Currents from Cardiac Gap Junctions1986 · 152 citations