Key result
Changes in NT-proBNP concentrations over 1 year were highly predictive of all-cause mortality (P=0.025) and hospitalizations (P<0.001) in patients with diabetes, unlike changes in HbA1c.
Why the study?
Do repetitive measurements of NT-proBNP and HbA1c predict mortality and hospitalizations in patients with longstanding diabetes?
Observational (n=544)
Do repetitive measurements of NT-proBNP and HbA1c predict mortality and hospitalizations in patients with longstanding diabetes?
p-value: p=<0.001
Serial measurements of NT-proBNP, but not HbA1c, are strongly predictive of mortality and hospitalizations in patients with longstanding diabetes, reflecting dynamic changes in cardiovascular risk.
NT-proBNP changes may refine risk stratification in longstanding diabetes; hypothesis-generating and requires prospective validation before guiding care.
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Neuhold et al. (2011) conducted an observational in diabetes mellitus (n=544). Repetitive measurements of HbA1c and NT-proBNP was evaluated on all-cause mortality, cardiac, cardiovascular and all-cause hospitalizations (p=<0.001). Changes in NT-proBNP concentrations over 1 year were highly predictive of all-cause mortality (P=0.025) and hospitalizations (P<0.001) in patients with diabetes, unlike changes in HbA1c.
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