Key result
Human-bovine rotavirus candidate vaccine induces rabbit IgA titers similar to human and bovine strains.
Why the study?
Does a human-bovine rotavirus candidate vaccine induce IgA antibody production in rabbits compared to PBS?
Does a human-bovine rotavirus candidate vaccine induce IgA antibody production in rabbits compared to PBS?
The candidate reassortant vaccine and cell adapted animal strains induced IgA production and could be used as vaccine candidates.
Supports reassortant as rotavirus vaccine candidate in rabbits; leaves open human immunogenicity and efficacy trials.
TCID50+zinc. The N2, N3, and N4 groups received rotavirus vaccine strain, RV4 human rotavirus, and bovine rotavirus strain, respectively, and the control group received phosphate-buffered saline. It is noteworthy that three rabbits have been included in each group. The IgA total antibody titer was measured and evaluated by non-parametric Mann-Whitney and Kruskal-Wallis tests. The antibody titer produced in the studied groups did not significantly differ. The candidate vaccine showed immunogenicity, protectivity, stability, and safety. The findings of this study indicated a critical role of IgA production, which can induce immunity against a gastroenteritis viral pathogen. Regardless of purification, candidate reassortant vaccine and cell adapted animal strains could be used as a vaccine candidate for production.
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Zafari et al. (2023) studied Rotavirus infection (n=12). Human-Bovine Rotavirus Candidate Vaccine vs. RV4 human rotavirus, bovine rotavirus strain, and phosphate-buffered saline was evaluated on IgA total antibody titer. A human-bovine rotavirus candidate vaccine induced IgA antibody titers in rabbits that did not significantly differ from those induced by RV4 human rotavirus or bovine rotavirus strains.
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