Why the study?
Do postvaccination antibody titers correlate with protection against rotavirus infection or disease in subjects receiving a rotavirus vaccine?
Population
Subjects in a reassortant rotavirus vaccine trial
Design
RCT
Authors
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Titers should not guide individual protection assessment; extends serotype-specific data but leaves reliable overall correlates unresolved.
Do postvaccination antibody titers correlate with protection against rotavirus infection or disease in subjects receiving a rotavirus vaccine?
Postvaccination rotavirus antibody titers show some correlation with protection against specific serotype illnesses, but no single titer serves as a reliable indicator of overall protection.
Ward et al. (1997) studied this question.
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