Why the study?
Does parenteral immunization with SA11 rotavirus induce active protective immunity in a rabbit model of rotavirus infection?
Population
Rabbit model of rotavirus infection
Comparison
One or two intramuscular injections of 1 ml of… vs Control rabbits
Design
Preclinical
Follow-up
Up to 71 days postvaccination
Authors
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Supports parenteral rotavirus vaccination in rabbit models; leaves open translation to human protective immunity.
Does parenteral immunization with SA11 rotavirus induce active protective immunity in a rabbit model of rotavirus infection?
Parenteral vaccination with two doses of rotavirus vaccine induces active protection from challenge in a rabbit model.
Conner et al. (1993) studied this question.
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