Why the study?
Does inactivated human rotavirus administered orally or intramuscularly induce protective immunity in newborn gnotobiotic pigs?
Population
Newborn gnotobiotic pigs
Design
Preclinical
Follow-up
20 to 24 days post-inoculation
Authors
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Systemic responses insufficient for mucosal protection in this model; leaves open optimal rotavirus vaccine platforms targeting intestinal immunity.
Does inactivated human rotavirus administered orally or intramuscularly induce protective immunity in newborn gnotobiotic pigs?
Inactivated human rotavirus administered orally or intramuscularly fails to induce protective intestinal IgA responses or confer significant protection against virulent challenge in gnotobiotic pigs.
Yuan et al. (1998) studied this question.
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