Population
Neonatal gnotobiotic pigs
Comparison
Oral inoculation with virulent Wa strain human… vs Inoculation with cell culture-attenuated Wa…
Design
Preclinical
Follow-up
21 days
Authors
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May guide rotavirus vaccine design targeting IgA responses; extends pig model data but leaves open human translation.
Intestinal and blood IgA antibody-secreting cells correlate with protective active immunity against human rotavirus in a gnotobiotic pig model.
Yuan et al. (1996) studied this question.
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