Population
Gnotobiotic pigs inoculated at 3 to 5 days of age
Comparison
Intraperitoneal injections of high-titer serum… vs Low-titer serum from naturally infected sows or…
Design
Preclinical
Follow-up
Up to postchallenge day 7
Authors
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High passive antibody titers may impair active rotavirus immunity; leaves open optimized vaccine strategies for infants with maternal antibodies.
High titers of passive maternal antibodies impair the induction of active antibody-secreting cells in response to rotavirus, highlighting the need for optimized vaccine strategies in infants with maternal antibodies.
Hodgins et al. (1999) studied this question.
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