Population
Gnotobiotic pigs (n=112), inoculated at 3 to 5 days of age.
Comparison
Oral inoculation with virulent Wa strain human… vs Oral inoculation with an equal volume of MEM…
Design
Preclinical
Follow-up
Up to 50 days post-inoculation
Authors
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LPA responses merit investigation as rotavirus protection markers in pigs; leaves open validation in human studies.
In a gnotobiotic pig model, virulent but not attenuated human rotavirus induced strong systemic and intestinal lymphoproliferative responses that correlated with protective immunity against subsequent challenge.
Ward et al. (1996) studied this question.
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