Key result
Parenteral bivalent rotavirus vaccine in pregnant monkeys reduces offspring diarrhea, viral load, and histopathological changes.
Why the study?
Live-attenuated rotavirus vaccine has shown low protection in underdeveloped or developing countries, and inactivated rotavirus vaccine may overcome these challenges.
Does a bivalent inactivated rotavirus vaccine administered to pregnant rhesus monkeys protect their offspring from rotavirus infection?
Does a bivalent inactivated rotavirus vaccine administered to pregnant rhesus monkeys protect their offspring from rotavirus infection?
Maternal vaccination with a bivalent inactivated rotavirus vaccine in rhesus monkeys provides transplacental antibody transfer and protects offspring from rotavirus infection.
Hypothesis-generating for inactivated rotavirus vaccines in neonates; prospective human trials needed before clinical consideration.
Live-attenuated rotavirus vaccine has shown low protection in underdeveloped or developing countries. However, the inactivated rotavirus vaccine may have the potential to overcome some of these challenges. In the present study, the immunogenicity and protective efficacy of a bivalent inactivated rotavirus vaccine by parenteral administration were elevated in a neonatal rhesus monkey model. A bivalent inactivated rotavirus vaccine containing G1P[8] (ZTR-68 strain) and G9P[8] (ZTR-18 strain) was administered to pregnant rhesus monkeys twice at an interval of 14 days. Neutralizing antibodies against RV strains ZTR-68, ZTR-18, SA11, WA, UK, and Gottfried emerged in pregnant rhesus monkeys and were transplacentally transmitted to the offspring. In the vaccine group, clinical symptoms of diarrhea, viral load in the gut tissue and histopathological changes were significantly reduced in the neonatal rhesus monkeys following oral challenge with the SA11 strain.
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Yin et al. (2021) studied Rotavirus infection. Bivalent inactivated rotavirus vaccine was evaluated on Clinical symptoms of diarrhea, viral load in the gut tissue and histopathological changes. Parenteral administration of a bivalent inactivated rotavirus vaccine to pregnant rhesus monkeys significantly reduced diarrhea, viral load, and histopathological changes in offspring.
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