Why the study?
Do orally administered RRV or DxRRV vaccines prevent rotavirus-associated illness in infants aged 2-4 months?
Population
223 infants 2-4 months old
Comparison
Orally administered live rhesus monkey rotavirus… vs Placebo
Design
RCT, placebo-controlled
Follow-up
over three rotavirus seasons
Authors
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Supports RRV or DxRRV vaccination in infants; extends evidence for multi-season protection.
Do orally administered RRV or DxRRV vaccines prevent rotavirus-associated illness in infants aged 2-4 months?
Both RRV and DxRRV vaccines are immunogenic and provide significant protection against rotavirus-associated illness over three seasons in infants.
Madore et al. (1992) studied this question.
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