Why the study?
Do human-rhesus rotavirus reassortant vaccines induce seroresponses and are they safe in infants?
Population
116 1- to 5-month-old infants in Caracas, Venezuela
Comparison
Oral administration of human-rhesus rotavirus… vs Placebo
Design
RCT, randomly divided into five groups, placebo-controlled double-blind
Follow-up
7 days for clinical reactions
Authors
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Supports advancing reassortant rotavirus vaccines in infants; extends immunogenicity data with acceptable reactogenicity for further trials.
Do human-rhesus rotavirus reassortant vaccines induce seroresponses and are they safe in infants?
Human-rhesus rotavirus reassortant vaccines are immunogenic and generally well-tolerated in infants, with VP4 protein playing an important role in the neutralization antibody response.
Flores et al. (1989) studied this question.
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