Key result
Four double gene substitution human x bovine rotavirus reassortant vaccine candidates were successfully generated to increase antigenicity, with safety and efficacy currently under evaluation.
The generation of double gene substitution human x bovine rotavirus reassortants provides new vaccine candidates that may offer increased antigenicity by incorporating two protective human rotavirus antigens (VP4 and VP7).
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New rotavirus reassortants expand vaccine options; leaves open clinical safety and efficacy in humans.
Hoshino et al. (1997) studied Rotavirus infection. Double gene substitution human x bovine rotavirus reassortant vaccine candidates was evaluated. Four double gene substitution human x bovine rotavirus reassortant vaccine candidates were successfully generated to increase antigenicity, with safety and efficacy currently under evaluation.
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