Single gene substitution rotavirus reassortants containing the major neutralization protein (VP7) of human rotavirus serotype 4

Cell cultures coinfected with wild-type bovine rotavirus (UK strain [serotype 6]) or rhesus rotavirus (strain MMU18006 [serotype 3]) and a tissue culture-adapted human rotavirus strain, ST3 (serotype 4)

Selection using monospecific antiserum or monoclonal antibodies to the major outer capsid neutralization glycoprotein, VP7, of the animal rotavirus parent

Isolation and characterization of reassortants with human rotavirus serotype 4 neutralization specificity