What question did this study set out to answer?

This study aims to investigate whether brain natriuretic peptide enhances myocardial performance during diastole.

February 1, 1995Clinical Science

Brain Natriuretic Peptide: Effect on Left Ventricular Filling Patterns in Healthy Subjects

View Full Paper

Ask AI

Bookmark

Why the study?

Does brain natriuretic peptide infusion improve left ventricular diastolic relaxation parameters in healthy subjects?

Population

9 normal (healthy) subjects

Comparison

Brain natriuretic peptide infusion vs Placebo infusion

Design

RCT, randomized, crossover, double-blind

Authors

PCPeter ClarksonFrimley Park Hospital NWNigel WheeldonInterventional Cardiology CMCatherine MacLeodNovartis (Switzerland)

Discussion

Member takes

Implication

BNP infusion enhances LV relaxation in healthy subjects; extends mechanistic evidence and supports targeted diastolic HF trials.

Key Points

This study aims to investigate whether brain natriuretic peptide enhances myocardial performance during diastole.
Nine normal subjects received infusions of brain natriuretic peptide or placebo in a randomized, double-blind, crossover design.
Measurements included isovolumic relaxation time and Doppler flow profiles before and after infusion.
Infusion of brain natriuretic peptide reduced isovolumic relaxation time by 10.8 ms (95% CI: -14.5 to -7.0, P < 0.01).
Peak E/A velocity increased by 0.54 (P < 0.05) and E/A time velocity integral increased by 1.09 (P < 0.05) after infusion.

Structured PICO

Does brain natriuretic peptide infusion improve left ventricular diastolic relaxation parameters in healthy subjects?

Population

9 normal (healthy) subjects

Intervention

Brain natriuretic peptide infusion

Comparator

Placebo infusion

Outcome

Isovolumic relaxation time, peak E/A velocity, and E/A time velocity integralsurrogate

Brain natriuretic peptide infusion improves left ventricular diastolic relaxation parameters in healthy subjects, suggesting a physiological role in diastolic function.

Cite This Study

Clarkson et al. (1995) studied this question.

synapsesocial.com/papers/6a0ec01a06ecbe833447c392 https://doi.org/10.1042/cs0880159

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark

Brain Natriuretic Peptide: Effect on Left Ventricular Filling Patterns in Healthy Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Brain Natriuretic Peptide: Effect on Left Ventricular Filling Patterns in Healthy Subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider