Key result
BNP infusion attenuated the rise in pulmonary capillary wedge pressure during exercise compared to placebo (16 vs 23 mm Hg; P < .01) in patients with isolated diastolic heart failure.
Why the study?
Does brain natriuretic peptide infusion improve exercise hemodynamics and neurohormones in patients with isolated diastolic heart failure?
Population
6 patients with isolated diastolic heart failure
Comparison
Infusion of brain natriuretic peptide (BNP) vs Placebo infusion (crossover design)
Design
RCT, randomized, single-blind
Follow-up
during incremental supine bicycle exercise after 30…
Authors
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Supports BNP infusion for exercise hemodynamics in isolated diastolic HF; extends natriuretic peptide evidence to HFpEF phenotypes.
RCT (n=6)
Single-blind
crossover
Does brain natriuretic peptide infusion improve exercise hemodynamics and neurohormones in patients with isolated diastolic heart failure?
Absolute Event Rate: 16% vs 23%
p-value: p=< .01
BNP infusion provides beneficial hemodynamic and neurohormonal effects during exercise in patients with isolated diastolic heart failure.
Clarkson et al. (1996) conducted an RCT in isolated diastolic heart failure (n=6). Brain natriuretic peptide (BNP) vs. placebo was evaluated on pulmonary capillary wedge pressure during exercise (p=< .01). BNP infusion attenuated the rise in pulmonary capillary wedge pressure during exercise compared to placebo (16 vs 23 mm Hg; P < .01) in patients with isolated diastolic heart failure.
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