What is the clinical evidence from this study?

Population: Myocardial infarction (n=14). Intervention: Harmonic phase (HARP) analysis vs. Homogeneous strain analysis. Primary outcome: Regional strain patterns (maximal stretch and shortening).

November 23, 2004Magnetic Resonance in MedicineOpen Access

Harmonic phase MR tagging for direct quantification of lagrangian strain in rat hearts after myocardial infarction

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Key result

Harmonic phase (HARP) analysis yielded similar results to conventional homogeneous strain analysis in assessing regional strain patterns, detecting reduced maximal stretch and shortening in infarct rats.

Why the study?

Does HARP analysis accurately quantify regional myocardial wall motion and strain in small animal models of myocardial infarction compared to conventional homogeneous strain analysis?

Key Points

This study investigates the accuracy of harmonic phase (HARP) analysis for automatic strain quantification in rat hearts following myocardial infarction.
Validation study with seven postinfarct rats and seven age-matched controls.
Development of a method for computing 2D Lagrangian strain fields from HARP images.
Comparison of HARP analysis with homogeneous strain analysis using finite element methods.
HARP analysis provided comparable results to conventional strain analysis in assessing regional strain patterns.
Both methods identified reduced maximal stretch and shortening in infarcted rats.
HARP analysis effectively quantified changes in regional myocardial wall motion in small animals.

Structured PICO

Does HARP analysis accurately quantify regional myocardial wall motion and strain in small animal models of myocardial infarction compared to conventional homogeneous strain analysis?

Population

14 rats (7 postinfarct rats and 7 age-matched controls)

Intervention

Harmonic phase (HARP) analysis for automatic strain quantification using tagged magnetic resonance images

Comparator

Homogeneous strain analysis employing finite element method and manual tag tracking

Outcome

Accuracy of HARP analysis for automatic strain quantification (regional strain patterns, maximal stretch and shortening)surrogate

HARP analysis is a valid and accurate method for automatic quantification of regional myocardial strain in small animal models.

Authors

WLWei LiuWinnMed JCJunjie ChenCentral South University SJSongbai JiWorcester Polytechnic Institute

Discussion

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Implication

HARP matches conventional strain analysis in rodent MI models; leaves open clinical translation pending human validation.

Cite This Study

Liu et al. (2004) studied Myocardial infarction (n=14). Harmonic phase (HARP) analysis vs. Homogeneous strain analysis was evaluated on Regional strain patterns (maximal stretch and shortening). Harmonic phase (HARP) analysis yielded similar results to conventional homogeneous strain analysis in assessing regional strain patterns, detecting reduced maximal stretch and shortening in infarct rats.

synapsesocial.com/papers/6a0ec07837aeb0126447a775 https://doi.org/10.1002/mrm.20276

Topics

Cardiac MRI

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Harmonic phase MR tagging for direct quantification of lagrangian strain in rat hearts after myocardial infarction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Harmonic phase MR tagging for direct quantification of lagrangian strain in rat hearts after myocardial infarction

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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