July 19, 2018Indian Heart JournalOpen Access

Co-Existence of hypertension worsens post-exercise cardiac autonomic recovery in type 2 diabetes

Q: What are the key findings of this study?

The co-existence of hypertension and type 2 diabetes significantly impaired post-exercise cardiac autonomic recovery, reducing heart rate recovery at 2 minutes to 42.8 bpm compared to 60.3 bpm in healthy controls.

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 Diabetes Mellitus and Hypertension (n=99). Intervention: Co-existence of Type 2 Diabetes and Hypertension vs. Healthy controls, normotensive diabetics, and non-diabetic hypertensives. Primary outcome: Heart rate recovery at 2 minutes (HRR2min) post-exercise (p=<0.05).

View Full Paper

Ask AI

Bookmark

Key result

Combined hypertension and type 2 diabetes linked to ~29% lower post-exercise heart rate recovery.

P<0.05
n=99

Why the study?

Does the co-existence of hypertension worsen post-exercise cardiac autonomic recovery in patients with type 2 diabetes?

Population

99 sedentary adults comprising 48 with type 2 diabetes, 24 non-diabetic patients with essential…

Comparison

Co-existence of type 2 diabetes and hypertension vs Healthy controls, type 2 diabetes alone, and…

Design

Cross-sectional

Authors

SVShalini VermaGoogle (United States)PBPooja BhatiAmrita Institute of Medical Sciences and Research Centre IAIrshad AhmadManav Rachna International Institute of Research and Studies

Discussion

Member takes

Implication

Associated with impaired post-exercise autonomic recovery in comorbid patients; hypothesis-generating and leaves open prognostic or interventional implications.

Study Design

Type

Cross-Sectional (n=99)

Multicenter

Structured PICO

Does the co-existence of hypertension worsen post-exercise cardiac autonomic recovery in patients with type 2 diabetes?

Population

99 sedentary adults (30-70 years old) comprising 48 with type 2 diabetes (24 normotensive, 24 hypertensive), 24 non-diabetic patients with essential hypertension, and 27 healthy controls.

Intervention

Co-existence of type 2 diabetes and hypertension (observational exposure)

Comparator

Healthy controls, type 2 diabetes alone, and hypertension alone

Outcome

Cardiac autonomic recovery assessed by heart rate recovery (HRR) at 1 and 2 minutes and heart rate variability (HRV) following a graded maximal treadmill exercise testsurrogate

Main Result

Absolute Event Rate: 42.8% vs 60.3%

p-value: p=<0.05

The co-existence of hypertension and type 2 diabetes synergistically impairs post-exercise cardiac autonomic recovery, highlighting a higher risk profile for autonomic dysfunction in these patients.

Limitations

Patients with structural abnormalities of the heart were not screened, meaning diabetic and hypertensive cardiomyopathies could have contributed to the blunt autonomic recovery.
The presence of cardiac autonomic neuropathy (CAN) was not objectively assessed by standard cardiovascular autonomic reflex tests.
Unavailability of echocardiography limits the results since diastolic dysfunction is common in these patients and might significantly interfere with autonomic function.
Structural abnormalities of the heart were not screened, so diabetic and hypertensive cardiomyopathies could have contributed
Cardiac autonomic neuropathy was not objectively assessed by standard cardiovascular autonomic reflex tests
Unavailability of echocardiography to assess diastolic dysfunction

Cite This Study

Verma et al. (2018) conducted a cross-sectional in Type 2 Diabetes Mellitus and Hypertension (n=99). Co-existence of Type 2 Diabetes and Hypertension vs. Healthy controls, normotensive diabetics, and non-diabetic hypertensives was evaluated on Heart rate recovery at 2 minutes (HRR2min) post-exercise (p=<0.05). The co-existence of hypertension and type 2 diabetes significantly impaired post-exercise cardiac autonomic recovery, reducing heart rate recovery at 2 minutes to 42.8 bpm compared to 60.3 bpm in healthy controls.

synapsesocial.com/papers/6a0ec3afb7cc3b883f22b5fc https://doi.org/10.1016/j.ihj.2018.06.007

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Associated with impaired post-exercise autonomic recovery in comorbid patients; hypothesis-generating and leaves open prognostic or interventional implications.

Co-Existence of hypertension worsens post-exercise cardiac autonomic recovery in type 2 diabetes

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Co-Existence of hypertension worsens post-exercise cardiac autonomic recovery in type 2 diabetes

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider