Key result
Primary aldosteronism links to lower lymphocyte counts and higher neutrophil-lymphocyte ratios versus essential hypertension.
Why the study?
Hypertensive patients with primary aldosteronism face higher cardiovascular risk than blood pressure-matched essential hypertension patients, which may be closely related to inflammation.
Does primary aldosteronism correlate with higher leukocyte-related inflammation compared to essential hypertension?
Observational (n=692)
No
Does primary aldosteronism correlate with higher leukocyte-related inflammation compared to essential hypertension?
Primary aldosteronism is associated with higher leukocyte-related systemic inflammation (elevated NLR and MLR) compared to matched essential hypertension, which may contribute to their higher cardiovascular risk.
May indicate heightened inflammation in primary aldosteronism; leaves open causal role in cardiovascular risk.
Background: Hypertension patients with primary aldosteronism (PA) have a higher risk of cardiovascular complications than blood pressure-matched essential hypertension (EH) patients. The cause may be closely related to inflammation. We explored the correlations between leukocyte-related inflammation parameters and plasma aldosterone concentration (PAC) in PA patients and clinical characteristics-matched EH patients. Methods: A total of 346 PA and 346 sex, age and 24-h blood pressure-matched EH patients at the 2nd Affiliated Hospital of Nanchang University from January 2020 to June 2021 were enrolled in this study. The differences and correlations of aldosterone and leukocyte parameters between the two groups were analyzed. Results: Compared with EH patients, the lymphocyte count was significantly lower (P = 0.004), the neutrophil-lymphocyte ratio (NLR) (P = 0.023) and the monocyte-lymphocyte ratio (MLR) (P = 0.037) were significantly higher in PA patients. Linear regression analysis and multivariate regression analysis identified that lymphocyte count, NLR and MLR were significantly and independently correlated with PAC in PA patients, and the correlations were stronger with increasing levels of aldosterone. However, in EH patients, only NLR maintained an independent correlation with PAC. Conclusion: Leukocyte-related inflammation parameters, including lymphocyte count, NLR, and MLR, were significantly and independently correlated with PAC in PA patients. The correlations were stronger with increasing levels of aldosterone. However, the above correlations were not always present in patients with EH matched for clinical characteristics.
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Rao et al. (2023) conducted an observational in Primary aldosteronism and essential hypertension (n=692). Primary aldosteronism vs. Essential hypertension was evaluated on Differences and correlations of aldosterone and leukocyte parameters. Primary aldosteronism was associated with lower lymphocyte counts (P=0.004) and higher neutrophil-lymphocyte (P=0.023) and monocyte-lymphocyte ratios (P=0.037) compared to essential hypertension.
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