Key result
Aldosterone-producing adenoma links to higher MMP-2, LV mass, and A velocity versus bilateral adrenal hyperplasia.
Why the study?
Are inflammatory markers related to oxidative stress associated with cardiac dysfunction and remodeling in patients with primary aldosteronism?
Population
32 subjects whose aldosterone-renin ratio was more than 30 among patients who visited Severance Hospital…
Design
Cross-sectional
Authors
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MMP-2 elevation in APA was associated with greater LV mass and diastolic dysfunction; hypothesis-generating for oxidative stress in aldosteronism remodeling.
Cross-Sectional (n=32)
No
Are inflammatory markers related to oxidative stress associated with cardiac dysfunction and remodeling in patients with primary aldosteronism?
Inflammatory markers related to oxidative stress may be involved in the development of diastolic dysfunction and left ventricular hypertrophy in patients with primary aldosteronism.
Lim et al. (2016) conducted a cross-sectional in Primary aldosteronism (n=32). Aldosterone-producing adenoma (APA) vs. Bilateral adrenal hyperplasia (BAH) was evaluated on Inflammatory markers and echocardiographic parameters. Patients with aldosterone-producing adenoma had significantly higher MMP-2 levels, left ventricular mass, and A velocity compared to those with bilateral adrenal hyperplasia.
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