June 29, 2014Journal of Hypertension
Oxidative stress in patients affected by primary aldosteronism
Key result
Primary aldosteronism was associated with significantly increased oxidative stress compared to essential hypertension, evidenced by higher Nox2-dp plasma levels (34.9 vs 27.1 μg/dl; P<0.05).
Why the study?
Does specific treatment of primary aldosteronism reduce oxidative stress markers?
Population
138 individuals, including 38 patients with primary aldosteronism, 50 patients with essential hypertension…
Comparison
Specific treatment for primary aldosteronism. vs Essential hypertension patients and healthy…
Design
Cohort
Authors
Discussion
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Implication
Oxidative stress link in primary aldosteronism is hypothesis-generating; leaves open whether targeted therapy reduces Nox2-dp.
Study Design
Type
Observational (n=138)
Structured PICO
Does specific treatment of primary aldosteronism reduce oxidative stress markers?
P
Population
138 participants including 38 with primary aldosteronism, 50 with essential hypertension, and 50 healthy individuals evaluated for oxidative stress parameters.
E
Exposure
Specific treatment for primary aldosteronism (surgical adrenalectomy for APA or pharmacological treatment).
C
Comparator
Essential hypertension patients and healthy individuals (for baseline comparison), and baseline values (for post-treatment comparison).
O
Outcome
Parameters of oxidative stress (plasma levels of NADPH oxidase [Nox2-dp] and urinary isoprostanes) at diagnosis and after specific treatment.surrogate
Main Result
Absolute Event Rate: 34.9% vs 27.1%
p-value: p=< 0.05
Primary aldosteronism is associated with increased oxidative stress compared to essential hypertension, which is significantly reduced following targeted treatment such as adrenalectomy.
Cite This Study
Petramala et al. (2014) conducted an observational in Primary aldosteronism (n=138). Primary aldosteronism vs. Essential hypertension was evaluated on NADPH oxidase (Nox2-dp) plasma levels (p=< 0.05). Primary aldosteronism was associated with significantly increased oxidative stress compared to essential hypertension, evidenced by higher Nox2-dp plasma levels (34.9 vs 27.1 μg/dl; P<0.05).