Key result
Primary aldosteronism was associated with higher CysC-GFR (P<0.05) and heavier proteinuria compared to essential hypertension, which decreased 1 year after adrenalectomy.
Why the study?
Does adrenalectomy or spironolactone treatment improve kidney function and intrarenal vascular changes in patients with primary aldosteronism?
Population
203 patients, comprising 130 with primary aldosteronism and 73 with essential hypertension as controls.
Comparison
Adrenalectomy or spironolactone treatment vs Essential hypertension controls and comparison…
Design
Cohort
Follow-up
1 year
Authors
Loading...
Supports renal benefit of adrenalectomy in primary aldosteronism; leaves open differential effects versus spironolactone and need for RCTs.
Observational (n=203)
Yes
Does adrenalectomy or spironolactone treatment improve kidney function and intrarenal vascular changes in patients with primary aldosteronism?
p-value: p=<0.05
Adrenalectomy, but not spironolactone, reverses kidney hyperfiltration and intrarenal vascular structural changes in patients with primary aldosteronism.
Wu et al. (2011) conducted an observational in Primary aldosteronism (n=203). Primary aldosteronism vs. Essential hypertension was evaluated on Cystatin C-based estimations of glomerular filtration rate (CysC-GFR) (p=<0.05). Primary aldosteronism was associated with higher CysC-GFR (P<0.05) and heavier proteinuria compared to essential hypertension, which decreased 1 year after adrenalectomy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: