Key result
Aspirin resistance, defined as persisting platelet activation despite therapeutic dosing, may explain a proportion of treatment failures in the secondary prevention of cardiovascular disease.
Population
Patients prescribed aspirin for the secondary prevention of cardiovascular disease
Design
Review
Authors
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May warrant caution against routine resistance testing; leaves open predictive utility pending standardized definitions and validation studies.
Aspirin resistance, characterized by persisting platelet activation despite therapeutic dosing, requires standardized definitions and further research to assess its clinical utility in predicting cardiovascular events.
Sanderson et al. (2005) conducted a review in Cardiovascular disease. Aspirin was evaluated. Aspirin resistance, defined as persisting platelet activation despite therapeutic dosing, may explain a proportion of treatment failures in the secondary prevention of cardiovascular disease.
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