Key result
Cardiac LGE-MRI and Doppler echo effectively assess myocardial alterations to differentiate dilated cardiomyopathy.
Meta-Analysis (n=1,314)
This review provides a comprehensive overview of the clinical manifestations, etiology, diagnosis, and management of dilated cardiomyopathy.
Supports LGE-MRI and echocardiography for DCM assessment; leaves open need for prospective validation.
Dilated cardiomyopathy is the most prevalent phenotype. It is a frequent cause of heart failure and the primary indication for heart transplantation. Although it has specific standardized criteria for diagnosis, the criteria establish DCM as a non-specific phenotype caused by genetic factors, environmental factors or a combination of both. The diagnosis consists of a wide range of other cardiomyopathies that lead to a dilated ventricular wall, which has made differential diagnosis challenging and many studies providing varying findings. The lack of specific clinical management guidelines has influenced the use of general management concepts of LV dysfunction and heart failure, which vary between studies. This paper reviews current evidence on DCM to provide a comprehensive understanding of its clinical manifestations, etiology, diagnosis and clinical management.
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Aref Albakri (2018) conducted a meta-analysis in Dilated cardiomyopathy (n=1,314). Cardiac imaging (Cardiac MRI, Echocardiography, CT, Nuclear imaging) was evaluated on Diagnostic and prognostic utility of cardiac imaging modalities. Cardiac LGE-MRI and Doppler echocardiography were clinically effective in assessing morphological and functional myocardial alterations suggestive of dilated cardiomyopathy and differentiating it from other causes.
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