What is the clinical evidence from this study?

Study design: Case Report. Population: Muscular Dystrophy and Cardiomyopathy (n=1).

What question did this study set out to answer?

To investigate the role and potential deficiency of dystrophin-associated glycoproteins, specifically adhalin, in muscular dystrophy accompanied by cardiomyopathy.

February 8, 1996New England Journal of MedicineOpen Access

Deficiency of a Dystrophin-Associated Glycoprotein (Adhalin) in a Patient with Muscular Dystrophy and Cardiomyopathy

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Key result

A patient with muscular dystrophy and cardiomyopathy was found to have a deficiency of a dystrophin-associated glycoprotein (adhalin).

Population

A patient with muscular dystrophy and cardiomyopathy

Design

Case_report

Authors

RFRicardo FadićPontificia Universidad Católica de Chile YSYoshihida SunadaUniversity of Iowa AWAndrew J. WaclawikUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

Should not yet alter management in muscular dystrophy; hypothesis-generating for adhalin’s role in cardiomyopathy.

Key Points

To investigate the role and potential deficiency of dystrophin-associated glycoproteins, specifically adhalin, in muscular dystrophy accompanied by cardiomyopathy.
Evaluated a patient presenting with muscular dystrophy and cardiomyopathy for defects in the dystrophin-glycoprotein complex.
Analyzed sarcolemmal components linking the intracellular cytoskeleton to extracellular laminin in skeletal and cardiac tissue.
Demonstrated a primary deficiency of the 50-kd dystrophin-associated glycoprotein adhalin associated with muscular dystrophy and cardiac involvement.
Identified disruption of the transmembrane linkage between the subsarcolemmal cytoskeleton and extracellular matrix components.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A patient with muscular dystrophy and cardiomyopathy

Identifies a deficiency of adhalin in a patient with muscular dystrophy and cardiomyopathy.

Cite This Study

Fadić et al. (1996) conducted a case report in Muscular Dystrophy and Cardiomyopathy (n=1). A patient with muscular dystrophy and cardiomyopathy was found to have a deficiency of a dystrophin-associated glycoprotein (adhalin).

synapsesocial.com/papers/6a0ec942aa1655e5fb22cc83 https://doi.org/10.1056/nejm199602083340604

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Deficiency of a Dystrophin-Associated Glycoprotein (Adhalin) in a Patient with Muscular Dystrophy and Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Deficiency of a Dystrophin-Associated Glycoprotein (Adhalin) in a Patient with Muscular Dystrophy and Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider