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November 1, 1993Journal of Biological ChemistryOpen Access

Primary structure and muscle-specific expression of the 50-kDa dystrophin-associated glycoprotein (adhalin).

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Population

Rabbit skeletal muscle, BIO 14.6 cardiomyopathic hamsters, mdx mice, and Duchenne muscular dystrophy patient…

Design

Preclinical

Authors

SRSteven L. RoberdsUppsala UniversityRARichard D. AndersonScottsdale Community CollegeOIOxana Ibraghimov‐BeskrovnayaVyne Therapeutics (United States)

Discussion

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Implication

No immediate clinical implications in DMD; leaves open post-translational mechanisms as therapeutic targets pending human validation.

Structured PICO

P
Population
Rabbit skeletal muscle, BIO 14.6 cardiomyopathic hamsters, mdx mice, and Duchenne muscular dystrophy (DMD) patient muscle samples
I
Intervention
cDNA cloning and expression analysis of 50-kDa dystrophin-associated glycoprotein (adhalin)
O
Outcome
Primary structure, amino acid sequence, and tissue-specific expression of 50-DAG

The cloning of 50-DAG (adhalin) reveals it is a muscle-specific protein whose down-regulation in DMD and mdx mice is likely post-translational.

Cite This Study

Roberds et al. (1993) studied this question.

synapsesocial.com/papers/6a8317da24ad758e22e8e5d4https://doi.org/10.1016/s0021-9258(20)80440-2
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  3. 3Identification of novel proteins unique to either transverse tubules (TS28) or the sarcolemma (SL50) in rabbit skeletal muscle.1990 · 50 citations
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