Key result
Genetic linkage analysis mapped a novel locus for dilated cardiomyopathy associated with rhythm and conduction abnormalities to chromosome 3p22-p25, with a maximum two-point lod score of 6.09.
Population
A family of German and Swiss ancestry with dilated cardiomyopathy associated with sinus node dysfunction…
Design
Phenotypic data interpreted without knowledge of genotype; genotypes scored…
Authors
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May inform screening in familial DCM with conduction disease; leaves open the causative gene and clinical translation.
Observational (n=30)
No
Effect estimate: LOD 6.09
A novel genetic locus for dilated cardiomyopathy associated with rhythm and conduction abnormalities was mapped to chromosome 3p22-p25, excluding several candidate genes and representing a first step toward disease gene identification.
Olson et al. (1996) conducted an observational in Dilated cardiomyopathy with abnormal cardiac automaticity and conduction (n=30). Genetic linkage analysis mapped a novel locus for dilated cardiomyopathy associated with rhythm and conduction abnormalities to chromosome 3p22-p25, with a maximum two-point lod score of 6.09.
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