Key result
Genetic linkage analysis in a 46-member family mapped the locus responsible for familial dilated cardiomyopathy to chromosome 1q32, with a peak multipoint LOD score of 6.37.
Population
A family of 46 members spanning four generations with familial dilated cardiomyopathy.
Design
Other
Authors
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Localizes familial DCM to 1q32; leaves open causal gene identification and validation in other cohorts.
Observational (n=46)
Effect estimate: LOD score 6.37
Identified a genetic locus on chromosome 1q32 responsible for familial dilated cardiomyopathy, providing insight into the molecular basis of the disease.
Durand et al. (1995) conducted an observational in Familial Dilated Cardiomyopathy (n=46). Genetic linkage analysis in a 46-member family mapped the locus responsible for familial dilated cardiomyopathy to chromosome 1q32, with a peak multipoint LOD score of 6.37.
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