Key result
Genetic linkage analysis mapped a novel locus for pure autosomal dominant familial dilated cardiomyopathy to a 9 cM region on chromosome 10q21-23 with a maximum LOD score of 3.91.
Population
One family consisting of 26 members, 12 of whom are affected with familial autosomal dominant dilated…
Design
Other, Echocardiographers determining phenotypic status were blinded to…
Authors
Loading...
Novel 10q21-23 locus for familial dilated cardiomyopathy; extends genetic heterogeneity but leaves causal gene identification open.
Observational (n=26)
No
This study identifies a novel genetic locus for pure autosomal dominant familial dilated cardiomyopathy on chromosome 10q21-10q23, further demonstrating genetic heterogeneity in the disease.
Bowles et al. (1996) conducted an observational in Familial autosomal dominant dilated cardiomyopathy (n=26). Genetic linkage analysis was evaluated on Pairwise LOD score for linkage to chromosome 10q21-23. Genetic linkage analysis mapped a novel locus for pure autosomal dominant familial dilated cardiomyopathy to a 9 cM region on chromosome 10q21-23 with a maximum LOD score of 3.91.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: