Key result
Concomitant incidental DVT was not associated with increased all-cause mortality in patients with cancer and incidental pulmonary embolism (HR 1.01; 95% CI 0.43-2.75; p=0.855).
Why the study?
In patients with cancer and incidental PE, the prognostic effect of concomitant incidental DVT was unknown.
Does the presence of concomitant incidental DVT affect all-cause mortality in patients with cancer and incidental pulmonary embolism?
Cohort (n=200)
Does the presence of concomitant incidental DVT affect all-cause mortality in patients with cancer and incidental pulmonary embolism?
Effect estimate: HR 1.01 (95% CI 0.43-2.75)
p-value: p=0.855
In patients with cancer and incidental pulmonary embolism, the presence of concomitant incidental DVT does not significantly affect all-cause mortality, whereas low weight and metastases are predictors of poorer survival.
Incidental DVT should not yet alter management in cancer patients with incidental PE; leaves open whether combined VTE burden refines prognosis in prospective studies.
In symptomatic acute pulmonary embolism (PE), the presence of deep vein thrombosis (DVT) is a risk factor for 30- and 90-day mortality. In patients with cancer and incidental PE, the prognostic effect of concomitant incidental DVT is unknown. In this retrospective study, we examined the effect of incidental DVT on all-cause mortality in such patients. Adjusted Cox multivariate regression analysis was used for relevant covariates. From January 2010 to March 2018, we included 200 patients (mean age, 65.3 ± 12.4 years) who were followed up for 12.5 months (interquartile range 7.4–19.4 months). Of these patients, 62% had metastases, 31% had concomitant incidental DVT, and 40.1% (n = 81) died during follow-up. All-cause mortality did not increase in patients with DVT (hazard ratio [HR] 1.01, 95% confidence interval [CI] 0.43–2.75, p = 0.855). On multivariate analysis, weight (adjusted HR 0.96, 95% CI 0.92–0.99, p = 0.032), and metastasis (adjusted HR 10.26, 95% CI 2.35–44.9, p = 0.002) were predictors of all-cause mortality. In conclusion, low weight and presence of metastases were associated with all-cause mortality, while presence of concomitant DVT was unrelated to poorer survival.
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Barca-Hernando et al. (2020) conducted a cohort in Cancer and incidental pulmonary embolism (n=200). Concomitant incidental DVT vs. No concomitant incidental DVT was evaluated on All-cause mortality (HR 1.01, 95% CI 0.43-2.75, p=0.855). Concomitant incidental DVT was not associated with increased all-cause mortality in patients with cancer and incidental pulmonary embolism (HR 1.01; 95% CI 0.43-2.75; p=0.855).
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