Key result
Symptomatic DVT at presentation linked to ~68% lower in-hospital mortality in intermediate-high risk PE.
Why the study?
The prognostic value of symptomatic DVT at presentation regarding the prognosis of acute PE is unknown.
Does symptomatic DVT at presentation reduce all-cause hospital mortality in patients with acute symptomatic pulmonary embolism?
Population
1604 hospitalized patients with MDCT-diagnosed symptomatic acute PE
Comparison
Symptomatic DVT vs no symptoms or signs of DVT across PE risk strata
Design
Registry-based cohort study
Follow-up
In-hospital
Authors
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Symptomatic DVT may identify intermediate-high-risk PE patients benefiting from thrombolysis; leaves open confirmation in randomized trials before practice change.
Cohort (n=1,604)
Does symptomatic DVT at presentation reduce all-cause hospital mortality in patients with acute symptomatic pulmonary embolism?
Odds Ratio: 0.32 (95% CI 0.164–0.627)
Absolute Event Rate: 7.1% vs 18.6%
p-value: p=0.001
Symptomatic DVT at presentation in patients with intermediate-high risk acute pulmonary embolism is associated with lower in-hospital mortality, potentially identifying a subgroup that benefits from thrombolysis.
Obradović et al. (2022) conducted a cohort in Acute symptomatic pulmonary embolism (n=1,604). Symptomatic deep vein thrombosis (DVT) vs. No symptoms or signs of DVT was evaluated on All-cause hospital mortality (in intermediate-high risk PE) (OR 0.320, 95% CI 0.164-0.627, p=0.001). Symptomatic DVT at presentation was associated with decreased in-hospital mortality in patients with intermediate-high risk pulmonary embolism (OR 0.320; 95% CI 0.164-0.627; P=0.001).
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