Why the study?
The impact of deep vein thrombosis location on acute pulmonary embolism prognosis remains uncertain.
Does concomitant upper-extremity DVT compared to lower-extremity DVT worsen mortality in patients with acute symptomatic pulmonary embolism?
Population
21 617 patients with acute symptomatic PE and concomitant DVT
Comparison
Upper-extremity DVT vs lower-extremity DVT
Design
Registry-based cohort study
Follow-up
90 days
Key result
Concomitant upper-extremity DVT in acute pulmonary embolism was associated with higher 30-day all-cause mortality compared to lower-extremity DVT (7.3% vs 3.5%; aHR 1.49; 95% CI 1.04-2.13).
Authors
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May inform PE risk stratification by DVT site; leaves open whether upper-extremity cases warrant distinct management.
Cohort (n=21,617)
Does concomitant upper-extremity DVT compared to lower-extremity DVT worsen mortality in patients with acute symptomatic pulmonary embolism?
Hazard Ratio: 1.49 (95% CI 1.04–2.13)
Absolute Event Rate: 7.3% vs 3.5%
p-value: p=<0.001
In patients with acute symptomatic pulmonary embolism, concomitant upper-extremity DVT is associated with a higher risk of short-term mortality compared to lower-extremity DVT.
Dubois-Silva et al. (2025) conducted a cohort in Acute symptomatic pulmonary embolism with concomitant deep vein thrombosis (n=21,617). Concomitant upper-extremity deep vein thrombosis (UEDVT) vs. Concomitant lower-extremity deep vein thrombosis (LEDVT) was evaluated on 30-day all-cause mortality (aHR 1.49, 95% CI 1.04 to 2.13, p=<0.001). Concomitant upper-extremity DVT in acute pulmonary embolism was associated with higher 30-day all-cause mortality compared to lower-extremity DVT (7.3% vs 3.5%; aHR 1.49; 95% CI 1.04-2.13).
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