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April 1, 1971CirculationOpen Access

Electrophysiological Significance of First Degree Atrioventricular Block with Intraventricular Conduction Disturbance

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Key result

In 27 patients with PR prolongation and intraventricular conduction defects, P-H was prolonged in most (including 8 of 12 with LBBB), while H-Q was prolonged in 10 of 12 patients with LBBB.

Why the study?

What are the electrophysiological characteristics of first-degree atrioventricular block with intraventricular conduction disturbance?

Population

27 patients with PR prolongation and intraventricular conduction disturbances

Design

Case_series

Authors

KRKenneth M. RosenBoston UniversitySRShahbudin H. RahimtoolaStructural Heart DiseaseRCRuben ChuquimiaJohn H. Stroger, Jr. Hospital of Cook County

Discussion

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Implication

May inform EP localization in first-degree AV block with LBBB; hypothesis-generating for conduction disease patterns.

Key Points

  • The study aims to investigate the electrophysiological characteristics of first-degree atrioventricular block in patients with intraventricular conduction disturbances.
  • Recorded His bundle electrograms in 27 patients with PR prolongation and intraventricular conduction disturbances.
  • Analyzed P-H and H-Q intervals to determine conduction abnormalities.
  • Performed atrial pacing and assessed conduction block at increased heart rates.
  • In patients with left bundle-branch block (LBBB), P-H was prolonged in 8 out of 12 patients, with an average of 173 msec.
  • In right bundle-branch block (RBBB), all 8 patients had prolonged P-H intervals, with an average of 206 msec.
  • Most patients showed prolonged H-Q intervals, particularly those with LBBB, suggesting significant conduction issues.

Study Design

Type

Observational (n=27)

Structured PICO

What are the electrophysiological characteristics of first-degree atrioventricular block with intraventricular conduction disturbance?

P
Population
27 patients with PR prolongation and intraventricular conduction disturbances (12 with left bundle-branch block [LBBB], 8 with right bundle-branch block [RBBB], 7 with lesser intraventricular conduction defects)
I
Intervention
His bundle electrogram recording, atrial pacing at increased heart rates, and atropine administration
O
Outcome
P-H interval (measure of atrioventricular conduction) and H-Q interval (measure of intraventricular conduction)surrogate

In patients with first-degree AV block and intraventricular conduction delay, PR prolongation is primarily due to AV nodal delay, but those with LBBB frequently have additional His-Purkinje system disease.

Cite This Study

Rosen et al. (1971) conducted an observational in PR prolongation and intraventricular conduction disturbances (n=27). His bundle electrogram recording was evaluated on P-H and H-Q intervals. In 27 patients with PR prolongation and intraventricular conduction defects, P-H was prolonged in most (including 8 of 12 with LBBB), while H-Q was prolonged in 10 of 12 patients with LBBB.

synapsesocial.com/papers/6a0ece45aa1655e5fb22d2ffhttps://doi.org/10.1161/01.cir.43.4.491
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bundle-branch Block in Acute Myocardial Infarction1969 · 67 citations
  2. 2Functional Properties of the Atrioventricular Conduction System1963 · 139 citations
  3. 3Complete Bundle-Branch Block Complicating Acute Myocardial Infarction1970 · 147 citations
  4. 4The Dissection of the Atrioventricular Node Bundle and Bundle Branches in the Human Heart1951 · 111 citations