Ischaemic ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%; p<0.001), despite definite CAD being more prevalent in men (6.1% vs 4.0%; p=0.009).
Cross-Sectional (n=3,143)
Yes
What is the prevalence of coronary artery disease and ECG evidence of ischaemia in middle-aged adults in urban Pakistan, and how does it differ by sex?
One in five middle-aged adults in urban Pakistan may have underlying CAD, with women showing significantly more ECG evidence of ischaemia than men despite lower rates of definite CAD history.
Absolute Event Rate: 29.4% vs 15.6%
p-value: p=<0.001
UNLABELLED: Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged >or=40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. Definite CAD (history and Q waves on ECG) was more prevalent in men than in women (6.1% vs 4.0%; p = 0.009). In contrast, ischaemic and major ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%, and 21.0% vs 10.5%; p<0.001 for each, respectively). All measures of CAD were strongly predicted by the metabolic syndrome, but that failed to account for the greater prevalence of ECG abnormalities in women than in men. The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men. TRIAL REGISTRATION NUMBER: NCT00327574.
Jafar et al. (Mon,) conducted a cross-sectional in Coronary artery disease (n=3,143). Female sex vs. Male sex was evaluated on Ischaemic ECG changes (p=<0.001). Ischaemic ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%; p<0.001), despite definite CAD being more prevalent in men (6.1% vs 4.0%; p=0.009).
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