Key result
Women present with ~67% lower baseline ASCVD risk scores than men despite prevalent risk factors.
Why the study?
The study aimed to assess modifiable cardiovascular disease risk factors among women versus men presenting for primary prevention at a tertiary care cardiac centre in Pakistan.
Are there differences in modifiable cardiovascular risk factors and estimated ASCVD risk scores between women and men presenting for primary prevention?
Population
Female and male individuals with no history of ischaemic heart disease referred for primary prevention in Pakistan
Comparison
Women vs men
Design
Observational study using a prospectively collected ongoing registry
Follow-up
Median 49.5 (7.0-231) days
Authors
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Suggests ASCVD calculators may underestimate risk in women despite modifiable factors; leaves open need for sex-specific validation studies.
Observational (n=535)
No
Are there differences in modifiable cardiovascular risk factors and estimated ASCVD risk scores between women and men presenting for primary prevention?
Absolute Event Rate: 2.25% vs 6.8%
p-value: p=<0.001
Women presenting for primary prevention have a high prevalence of modifiable risk factors but significantly lower calculated ASCVD risk scores compared to men, suggesting potential discrepancies in risk estimation or the contribution of non-modifiable factors.
Rauf et al. (2024) conducted an observational in Cardiovascular disease primary prevention (n=535). Women vs. Men was evaluated on Baseline ASCVD risk score (p=<0.001). Women presenting for primary prevention had a significantly lower median baseline ASCVD risk score compared to men (2.25% vs 6.8%, p<0.001), despite a high prevalence of modifiable risk factors.
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