The development of this microfluidic model enables in vitro investigation of how arrhythmic blood flow affects endothelial cell biology at the molecular level.
Enables in vitro modeling of arrhythmic flow on endothelium; hypothesis-generating and requires in vivo validation before clinical relevance.
We created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro . This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.
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Lai et al. (2024) studied this question.
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