Prospective Study of Depressive Symptoms and Risk of Stroke Among Japanese
Key result
High depressive symptoms significantly increased the risk of total stroke (RR 1.9; 95% CI, 1.1 to 3.5) and ischemic stroke (RR 2.7; 95% CI, 1.2 to 6.0) compared to low symptoms in Japanese adults.
Why the study?
Do high depressive symptoms increase the incidence of stroke in Japanese men and women aged 40 to 78 years?
Population
901 men and women aged 40 to 78 years in a rural Japanese community
Comparison
High tertile of depressive symptoms measured by… vs Low tertile of depressive symptoms measured by…
Design
Cohort
Follow-up
10.3 years
Authors
Discussion
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Implication
Depression screening may aid stroke risk stratification; leaves open whether treatment modifies risk in Japanese adults.
Study Design
Type
Cohort (n=901)
Multicenter
No
Structured PICO
Do high depressive symptoms increase the incidence of stroke in Japanese men and women aged 40 to 78 years?
P
Population
901 men and women aged 40 to 78 years in a rural Japanese community
I
Intervention
High tertile of depressive symptoms measured by Zung Self-Rating Depression Scale (SDS) at baseline
C
Comparator
Low tertile of depressive symptoms measured by Zung Self-Rating Depression Scale (SDS) at baseline
O
Outcome
Incidence of stroke ascertained under systematic surveillance over 10.3 yearshard clinical
Main Result
Effect estimate: RR 1.9 (95% CI 1.1 to 3.5)
Depressive symptoms are an independent predictor of incident stroke, particularly ischemic stroke, in a Japanese community cohort.
Cite This Study
Ohira et al. (2001) conducted a cohort in Stroke (n=901). High depressive symptoms (high tertile SDS score) vs. Low depressive symptoms (low tertile SDS score) was evaluated on Incidence of total stroke (RR 1.9, 95% CI 1.1 to 3.5). High depressive symptoms significantly increased the risk of total stroke (RR 1.9; 95% CI, 1.1 to 3.5) and ischemic stroke (RR 2.7; 95% CI, 1.2 to 6.0) compared to low symptoms in Japanese adults.