Key result
Warfarin alone or combined with aspirin was superior to aspirin alone for the composite of death, reinfarction, or stroke after MI (combination vs aspirin: RR 0.71; 95% CI 0.60-0.83; P=0.001).
Why the study?
Does warfarin alone or in combination with aspirin reduce the composite of death, nonfatal reinfarction, or thromboembolic cerebral stroke compared to aspirin alone in patients after myocardial infarction?
Population
3,630 patients after myocardial infarction
Comparison
Warfarin alone or Warfarin combined with Aspirin… vs Aspirin alone for a mean of four years
Design
RCT, randomized
Follow-up
mean four years
Authors
Loading...
Supports warfarin post-MI for ischemic prevention; confirms RCT superiority over aspirin alone.
RCT (n=3,630)
Yes
Does warfarin alone or in combination with aspirin reduce the composite of death, nonfatal reinfarction, or thromboembolic cerebral stroke compared to aspirin alone in patients after myocardial infarction?
Effect estimate: RR 0.71 (95% CI 0.60-0.83)
Absolute Event Rate: 15% vs 20%
p-value: p=0.001
In patients after myocardial infarction, warfarin alone or combined with low-dose aspirin reduces the risk of death, reinfarction, or stroke compared to aspirin alone, but significantly increases the risk of major bleeding.
Hurlen et al. (2002) conducted an RCT in Myocardial infarction (n=3,630). Warfarin combined with aspirin vs. Aspirin 160 mg daily was evaluated on Composite of death, nonfatal reinfarction, or thromboembolic cerebral stroke (RR 0.71, 95% CI 0.60-0.83, p=0.001). Warfarin alone or combined with aspirin was superior to aspirin alone for the composite of death, reinfarction, or stroke after MI (combination vs aspirin: RR 0.71; 95% CI 0.60-0.83; P=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: