Warfarin alone or with aspirin was superior to aspirin alone after acute myocardial infarction but increased bleeding

(2002) N Engl J Med 347, 969. Hurlen M, Abdelnoor M, Smith P, et al. . Warfarin, aspirin, or both after myocardial infarction. . ; . : . –74 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In patients who had an acute myocardial infarction (MI), what is the efficacy and safety of long term treatment with warfarin plus aspirin, warfarin alone, or aspirin alone? Randomised (allocation concealed*), blinded {data collectors, outcome assessors, monitoring committee, and data analysts}†,* controlled trial with mean follow up of 1445 days (about 4 y) (Warfarin, Aspirin, Reinfarction Study [WARIS II]). 20 hospitals in Norway. 3630 patients <75 years of age who were admitted to hospital for, and had survived, an acute MI. Exclusion criteria included malignant disease. Follow up was 99.6%. Patients were allocated to warfarin, with the goal of achieving an international normalised ratio (INR) of … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DHurlen%26rft.auinit1%253DM.%26rft.volume%253D347%26rft.issue%253D13%26rft.spage%253D969%26rft.epage%253D974%26rft.atitle%253DWarfarin%252C%2BAspirin%252C%2Bor%2BBoth%2Bafter%2BMyocardial%2BInfarction%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa020496%26rft_id%253Dinfo%253Apmid%252F12324552%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa020496&link_type=DOI [3]: /lookup/external-ref?access_num=12324552&link_type=MED&atom=%2Febmed%2F8%2F2%2F42.atom [4]: /lookup/external-ref?access_num=000178178400002&link_type=ISI