Key result
Intracardiac echocardiography is linked to ~11% shorter PVI time and improved ablation efficiency vs x-ray guidance.
Why the study?
Intracardiac echocardiography provides real-time imaging that may improve procedural outcomes compared to traditional x-ray guidance during pulmonary vein isolation for atrial fibrillation.
Does intracardiac echocardiography improve procedural efficiency and lesion quality compared to traditional x-ray guidance in patients undergoing pulmonary vein isolation for atrial fibrillation?
Cohort (n=126)
No
Does intracardiac echocardiography improve procedural efficiency and lesion quality compared to traditional x-ray guidance in patients undergoing pulmonary vein isolation for atrial fibrillation?
Intracardiac echocardiography guidance during pulmonary vein isolation for atrial fibrillation significantly improves procedural efficiency, lesion quality, and reduces 12-month AF recurrence in persistent AF patients compared to traditional x-ray guidance.
Background Pulmonary vein isolation (PVI) is a cornerstone of catheter ablation for atrial fibrillation (AF). Intracardiac echocardiography (ICE) offers real-time imaging that may enhance procedural outcomes compared to traditional x-ray guidance. This study evaluates the impact of ICE on PVI lesion quality and efficiency using a novel Ablation Index Functional Validation (AIFV) system. Methods This single-center, retrospective, matched cohort study included AF patients undergoing catheter ablation between June 2022 and June 2023 at The Third Affiliated Hospital of Nanjing Medical University. Patients were grouped based on ICE use (ICE vs. No-ICE), with intraoperative data recorded via the VisiTag system and analyzed by AIFV. Propensity score matching (1:1) was applied to compare procedural efficiency and lesion quality (primary endpoints) and AF recurrence (secondary endpoint) between groups. Results Of 126 patients enrolled (61 ICE, 65 No-ICE), 46 matched pairs were analyzed. PVI was achieved in all cases without severe complications. The ICE group demonstrated significantly shorter total PVI time [2,819 s (2,565 s, 2,953 s) vs. 3,153 s (2,696 s, 3,831 s), p = 0.006], higher radiofrequency (RF) time ratio (59.1% ± 13.9% vs. 48.2% ± 11.6%, p < 0.001), and higher effective ablation-index (AI) ratio (96.1% ± 4.5% vs. 91.2% ± 3.9%, p < 0.001) compared to the No-ICE group. Left and right PVI times were also reduced ( p = 0.034 and p = 0.029, respectively). At 12-month follow-up, AF recurrence rates were significantly lower in the ICE group (7.7% vs. 30.8%, p = 0.038) in persistent AF patients. Conclusion ICE enhances the quality of lesions and the ablation efficiency of PVI in AF patients, as shown by the AIFV system.
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Deng et al. (2025) conducted a cohort in Atrial fibrillation (n=126). Intracardiac echocardiography (ICE) vs. X-ray guidance (No-ICE) was evaluated on Total pulmonary vein isolation (PVI) time in seconds (β -334.2, 95% CI -567.8 to -100.6, p=0.005). Intracardiac echocardiography significantly reduced total pulmonary vein isolation time (median 2,819 vs 3,153 seconds) and improved ablation efficiency compared to x-ray guidance in patients with atrial fibrillation.
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