Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides

Antagonism of streptomycin activity by culture filtrates of Pseudononas aerugino8a was first reported by Sureau, Arquie, Boyer & Saviard (1948). The factor responsible for the antagonism was isolated The present paper describes an investigation of some of the biological properties of these compounds; part of this work has already been briefly reported (Lightbown & Jackson, 1954; Jackson & Light- bown, 1955).